PSG Portfolio

Current Studies

Updated on: 12/03/2012

3 Industry Sponsored studies

52 Publically Funded Studies

Publically Funded Studies

Acronym	Full Study Title	Chief Investigator	LRN Sites and PI’s	Current Status
AIRS	An open randomised study of auto inflation in school age children (4-11 years) with otitis media with effusion (OME) in primary care	Dr Ian Williamson	Leighton Hospital	Ongoing
BACTERIAL MENINGITIS IN INFANTS	Bacterial meningitis in infants less than 90 days of age: Assessment of healthcare delivery	Dr Paul Heath	Dr A Riordan Alder Hey Children’s Hospital Countess of Chester Hospital Dr M Turner Liverpool Women’s Hospital Dr S Burns Leighton Hospital	Ongoing
BAPS-CASS	Before, during and after birth - how does care affect the future health prospects of infants with congenital diaphragmatic hernia	Dr Jenny Kurinczuk	Prof P Losty Alder Hey Children’s Hospital	Ongoing
CAPS	A prospective study of childhood onset inflammatory arthritis	Dr Wendy Thomson - University of Manchester	Dr E Baildam Alder Hey Children’s Hospital	Ongoing
CDSS	The Children with Down's Syndrome Study	Prof Eve Roman	Dr L Newby Countess of Chester Hospital Dr I Losa Macclesfield Hospital Dr N Subhedar Liverpool Womens Hospital Dr J Ellison Leighton Hospital Dr S Gardner Southport & Ormskirk Hospitals Dr D Manning Arrowe Park Hospital	Ongoing
CF REGISTRY	CF Registry Study	-	Whiston Hospital	Ongoing
CHINA	The Children’s Interval Appendicectomy (CHINA) Study	Mr Nigel Hall – Southampton University Hospitals NHS Trust	Dr H Corbett Alder Hey Children’s	Ongoing
ChiP II	Towards a better understanding of hyperglycaemia in critically ill children. A sub-study of the Control of Hyperglycaemia in Paediatric intensive care (ChiP) trial	Dr Kevin Morris	Dr Morris/Dr Baines Alder Hey Children’s Hospital	Closed follow up complete
Complement C1q auto-antibody in glomerulonephritis	National study of membranoproliferative glomerulonephritis (mesangiocapillary glomerulonephritis) and Dense Deposit Disease	Dr C Mark Taylor – Birmingham Children’s Hospital	Dr J Russell Alder Hey Children’s Hospital	Closed follow up complete
CoTHENSS	Characterisation of Transplanted Human Enteric Nervous System stem cell behaviour in human mature muscle models	Mr Simon Kenny – Alder Hey Children’s Hospital	Dr D Wilkinson Alder Hey Children’s Hospital	Ongoing
CSAG II (Cleft Palate UK)	Evaluation of centralisation in cleft lip and palate	Prof Andy Ness	Dr R Joyce Alder Hey Children’s Hospital	Ongoing
Developing a stem cell based therapy to replace nephrons lost through reflux nephropathy	Developing a stem cell based therapy to replace nephrons lost through reflux nephropathy	Mr Simon Kenny – Alder Hey Children’s Hospital	Mr S Kenny Alder Hey Children’s Hospital Alder Hey	Suspended
DNSIYC	Diet & Nutrition Survey of Infants & Young Children	Dr Alison Lennox - University of Cambridge	Ms A Holmes Alder Hey Children’s Hospital	Closed follow up complete
DRN 494 (Antithyroid drug treatment in paediatric graves' disease) (thyrotoxicosis)	DRN 494 (Antithyroid drug treatment in paediatric graves' disease) (thyrotoxicosis)	Dr Tim Cheetham - Newcastle University	Dr J Blair Alder Hey Children’s Hospital	Suspended
EASYPOD	Saizen® [somatropin (rDNA origin) for injection] is indicated for the treatment of children with growth failure due to inadequate secretion of endogenous growth hormone.	-	Dr J Blair Alder Hey Children’s Hospital	Ongoing
EPICure 2	EPICure 2: Growing up after extremely preterm birth	Prof Kate Costeloe	Dr M Turner Liverpool Women’s Hospital	Closed follow up complete
European registry of diarrhoea negative haemolytic uraemic syndrome in childhood	European registry of diarrhoea negative haemolytic uraemic syndrome in childhood	-	Alder Hey Children’s Hospital	Closed follow up complete
FiCTION Feasibility Study	Filling Children's Teeth: Indicated or Not?	Dr Nicola Innes	Alder Hey Children’s Hospital	Closed follow up complete
Follow-up study examining the health of children with Down's syndrome	Follow-up study examining the health of children with Down's syndrome	Dr Paresh Vyas	Alder Hey Children’s Hospital	Closed follow up complete
Genetic susceptibility to papilloma-induced voice disturbance	Genetic susceptibility to papilloma-induced voice disturbance	-	Dr A Donne Alder Hey Children’s Hospital	Ongoing
Genetics of Learning Disability	Syndromic epilepsy and learning disability: characterisation of phenotype and detection of pathogenic genomic copy number variations.	Prof Mike Kerr	Dr R Appleton Alder Hey Children’s Hospital	Ongoing
GO-CHD	Genetic Origins of Congenital Heart Disease	Prof Reza Razavi	Dr E Ladusans Alder Hey Children’s Hospital	Closed follow up complete
Gold (Find)	Investigation of the role of genomic deletions and duplications of an X-chromosome as a cause of X-linked learning disabilities	Dr F L Raymond	Dr A Fryer Alder Hey Children’s Hospital	Ongoing
GOOS	Genetics of Obesity	Prof I S Farooqi	Whiston Hospital	Suspended
Healthtalkonline	Children, young people and parents' experience of clinical trials	Dr Lesley Powell - University of Oxford	No PI needed Alder Hey Children’s Hospital No PI needed Macclesfield Hospital	Closed follow up complete
I-BASIS	Intervention within the British Autism Study of Infant Siblings	Prof Jonathan Green	Alder Hey Children’s Hospital Countess of Chester Hospital	Ongoing
LAMB	Liverpool Archive of MRI in Neonates 'Babies'	Dr Mark Turner - Liverpool Women's NHS Foundation Trust	Dr L Abernethy Alder Hey Children’s Hospital Dr Mark Turner Liverpool Women’s Hospital	Ongoing
Longitudinal preterm Growth	Longitudinal preterm Growth Study	-	Whiston Hospital	Ongoing
Measuring Clinical Severity in Infants with Bronchiolitis	Measuring Clinical Severity in Infants with Bronchiolitis	Dr Paul McNamara – Alder Hey Children’s Hospital	Dr P McNamara Alder Hey Children's Hospital	Ongoing
Monitoring trends in Cerebral Palsy	Merseyside and Cheshire Cerebral Palsy Register: Monitoring trends in Cerebral Palsy	Dr Mary Platt - University of Liverpool	Dr Mary Platt Alder Hey Children’s Hospital	Closed follow up complete
Microarray profiling in Juvenile Idiopathic arthritis patients	Microarray profiling in Juvenile Idiopathic arthritis patients	Prof Patricia Woo - University College London	Prof Michael Beresford Alder Hey Children’s Hospital	Ongoing
MfN	Medicines for neonates	Prof Neena Modi	Alder Hey Children’s Hospital Countess of Chester Hospital Macclesfield Hospital Dr M Turner Liverpool Women’s Hospital Dr A Thirumirugan Leighton Hospital Dr H Satish Warrington Hospital	Ongoing
MOSAIC	Mechanisms Of Severe Acute Influenza Consortium	Prof Peter Openshaw	Dr C Semple Alder Hey Children’s Hospital Prof Z Alfirevic Liverpool Women’s Hospital	Closed follow up complete
MUCIN	The role of mucin production in the pathogenesis of paediatric respiratory disease	Dr Paul McNamara - Alder Hey Children’s Hospital	Dr P McNamara Alder Hey Children’s Hospital	Ongoing
National Repository (JIA genetics consortium)	Investigation of clinical, serological and genetic factors in the development of arthritis and rheumatic diseases	Prof Jane Worthington	Dr E Baildam Alder Hey Children’s Hospital Whiston Hospital	Ongoing
PEPSIN	Pepsin as a biomarker of pulmonary aspiration in children with CP	Dr Paul McNamara - Alder Hey Children’s Hospital	Dr P McNamara Alder Hey Children’s Hospital	Ongoing
PLUTO	Percutaneous shunting for Lower Urinary Tract Obstruction	Prof Mark Kilby	Alder Hey Children’s Hospital Liverpool Women’s Hospital	Closed follow up complete
Prion Surveillance in Primary Immunodeficiency	Prion Surveillance in Primary Immunodeficiency	Dr Matthew Helbert	Dr A Riordan Alder Hey Children’s Hospital	Suspended
RESCUEicp	Randomised Evaluation of Surgery with Craniectomy for Uncontrollable Elevation of Intra-Cranial Pressure	Dr Peter Hutchinson	Dr M Horan Alder Hey Children’s Hospital	Closed follow up complete
Respiratory syncytial virus (RSV) bronchiolitis: Clinical and Immunological associations in infancy	Respiratory syncytial virus (RSV) bronchiolitis: Clinical and Immunological associations in infancy	Prof R L Smyth - Alder Hey Children's Hospital	Dr C Semple Alder Hey Children’s Hospital	Closed follow up complete
SHIFT	Self- harm intervention, family therapy: a randomised controlled trial of family therapy vs. treatment as usual for young people seen after second or subsequent episodes of self-harm	Prof David Cottrell	Whiston Hospital	Ongoing
SLEEP	SLEEP (Sleep and behaviour problem services for disabled children)	Dr Bryony Beresford	Alder Hey Children’s Hospital	Closed follow up complete
SPICED	Development of a rapid salivary test to detect serious bacterial infection in children presenting to the accident and emergency department	Dr Enitan D Carrol - University of Liverpool	Dr E Carrol Alder Hey Children`s Hospital	Ongoing
The CHANGE Study	Congenital Hearts: a National Gene/Environment Study	Prof Judith Goodship - Newcastle University	Alder Hey Children’s Hospital	Closed follow up complete
The role of MDTs in causing Pharmacoresistance in Epilepsy	The role of MDTs in causing Pharmacoresistance in Epilepsy	Prof Tony Marson - University of Liverpool	Dr R Appleton Alder Hey Children’s Hospital	Ongoing
The role of Microcirculation in the Pathophysiology of Meningococcal Disease	The role of Microcirculation in the Pathophysiology of Meningococcal Disease	Dr Enitan D Carrol - University of Liverpool	Dr E Carrol Alder Hey Children`s Hospital	Closed follow up complete
The role of neutrophils and TLRs in severe RSV bronchiolitis	The role of neutrophils and TLRs in severe RSV bronchiolitis	Prof R L Smyth - Alder Hey Children's Hospital	Prof R L Smyth Alder Hey Children's Hospital	Suspended
OPPTIMUM	Does progresterone prophylaxis to prevent preterm labour improve outcome? – a randomised double blind placebo controlled trial	Prof Jane Norman	Dr Z Alfievic Liverpool Women’s Hospital Dr S Pinto Leighton Hospital Dr S Sharma Southport & Ormskirk Hospital Dr R Arya Warrington Hospital Dr S Mwenechanya Arrowe Park Hospital	Ongoing
TIDES-CF	The International depression/anxiety epidemiology study in CF –UK	Mr Alexander Quittner	Dr K Southern Alder Hey Children’s Hospital	Ongoing
TOPS	Timing of Primary Surgery for Cleft Palate v1.1	Prof William Shaw	S McMahon Alder Hey Children’s Hospital	Ongoing
Young people with DSD experiences of communication	Young people with DSD experiences of communication	Caroline Sanders - Alder Hey Children's Hospital	C Sanders Alder Hey Children's Hospital	Ongoing
Knowledge of Epilepsy at Transition	Knowledge of Epilepsy at Transition	Alder Hey Children's Hospital	Alder Hey Children's Hospital	In Setup
The Space Study	The Specificity of Pseudomonas Aeruginosa detection by hydrogen Cyanide concentration in Exhaled breath (the SPACE study)	Prof Warren Lenney	Alder Hey Children’s Hospital	In Setup
BASICS	More information coming soon	More information coming soon	Alder Hey Children’s Hospital	In Setup
MOMENT	More information coming soon	More information coming soon	Alder Hey Children’s Hospital	In Setup
URBAN-CF	Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Children with Cystic Fibrosis	Prof Rosalind Smith	Alder Hey Children’s Hospital	In Setup
VIPS	More information coming soon	More information coming soon	Alder Hey Children’s Hospital	In Setup

Industry Funded Studies

Cost of illness

Cost of illness in Cystic Fibrosis

Dr Hillary Wyatt - Westminster Hospital, University of London

Dr K Southern

Alder Hey Children’s Hospital

Ongoing

Empyema

The national programme for enhanced pneumococcal surveillance of complicated pneumococcal pneumonia and empyema in UK children

Dr David Spencer

Dr Enitan D Carrol

Alder Hey Children`s Hospital

Ongoing

Mechanism of propranolol on haemangiomas

Investigating the therapeutic mechanism of propranolol on haemangiomas

Dr A Donne

Alder Hey Children`s Hospital

Ongoing