Current Studies
Portfolio last updated on: 07/02/2012
94 Studies
27 Industry Sponsored
62 Publically Funded Studies
5 Investigator-Led Industry Funded
Publically Funded Studies
|
Acronym
|
Full Study Title |
Chief Investigator |
LRN Sites and PI’s |
Current Status |
|
ADEPT
|
Abnormal Doppler Enteral Prescription Trial |
Prof Peter Brocklehurst (National Perinatal Epidemiology Unit [NPEU], Oxford) |
Glan Clywd Hospital PI: Dr Ian Bernard Wrexham Hospital PI: Dr Ros Jones Leighton Hospital PI: Dr A Thirumurugan Countess of Chester Hospital PI: Dr Liz Newby |
Closed follow up complete |
|
ADRIC 1 |
Adverse Drug Reactions among children admitted acutely to hospital |
Prof Rosalind Smith |
Alder Hey Children’s NHS Foundation Trust PI: Ruairi Gallagher |
Closed follow up complete |
|
ADDRESS |
After Diagnosis Diabetes Research Support System |
Prof Des Johnston |
Alder Hey Children’s NHS Foundation Trust PI: TBC Countess of Chester Hospital PI: Dr Noel Murphy Macclesfield Hospital PI: Dr Chandrasekaran Whiston Hospital PI: TBC Warrington Hospital PI: Dr Nick Wild
|
Ongoing |
|
ADDRESS II |
After Diagnosis Diabetes Research Support System + blood sample |
Prof Des Johnston |
Site selection to be confirmed |
Ongoing |
|
ADRIC QUAL |
Adverse Drug Reactions among children admitted acutely to hospital |
Prof Rosalind Smith |
Alder Hey Children’s NHS Foundation Trust PI: Ruairi Gallagher |
Ongoing |
|
ADRIC 2 |
Adverse Drug Reactions in Children Study 2 – in-patient study |
Prof Rosalind Smith |
Alder Hey Children’s NHS Foundation Trust PI: Ruairi Gallagher |
Ongoing |
|
BILAG |
BILAG Biologics Prospective Cohort: The Use of Novel Biological Therapies in the Treatment of Systemic Lupus Erythematosus (SLE) |
Prof Ian Bruce |
Alder Hey Children’s NHS Foundation Trust PI: Dr Michael Beresford |
In Setup |
|
BOOST II |
Which oxygen saturation level should we use for very premature infants? A randomised controlled trial. |
Prof Peter Brocklehurst (National Perinatal Epidemiology Unit [NPEU], Oxford) |
Liverpool Women’s Hospital PI: Dr Nim Subedhar |
Closed In Follow Up |
|
BRACeLET |
Death in the context of a randomised controlled trial: a methodological study of policy and practice in neonatal and paediatric intensive care trials. |
Prof Diana Elbourne (London School of Hygiene & Tropical Medicine) |
Alder Hey Children’s NHS Foundation Trust |
Closed follow up complete |
|
CADDY |
Cessation of attention deficit hyperactivity disorder drugs in the young |
Prof Ian Wong (The School of Pharmacy, University of London) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Ruwan De Soysa |
Closed follow up complete |
|
CASG 112 |
Valganciclovir Therapy in infants with symptomatic Congenital Cytomegalovirus Infection |
Prof Paul Griffiths |
Alder Hey Children’s NHS Foundation Trust PI: Dr Andrew Riordan Liverpool Women’s Hospital PI: TBC Countess of Chester Hospital PI: TBC |
Closed follow up complete |
|
CHIP |
Control of Hyperglycaemia in paediatric intensive care. |
Dr Duncan Macrae (Royal Brompton & Harefield NHS Trust) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Paul Baines |
Closed follow up complete |
|
CHIP HIV |
A Cohort study of HIV infected children in UK & Ireland |
Prof Diana Gibb |
No sites but accrual count |
Closed follow up complete |
|
CROHNS GT |
Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn’s Disease |
Dr M Stephen Murphy (Birmingham Children’s Hospital) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Mark Dalzell |
Closed follow up complete |
|
DECIDE |
Delivering early care in diabetes evaluation: randomised controlled trial to assess hospital versus home management at diagnosis in childhood diabetes |
Prof John Gregory (Cardiff University) Dr Lesley Lowes (Cardiff University) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Pruicy Paul |
Closed follow up complete |
|
DEPICTED |
Development and evaluation of a psychosocial intervention for children and teenagers experiencing diabetes |
Prof John Gregory (Cardiff University) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Francesca Amman |
Closed follow up complete |
|
FOR DMD |
The Duchenne Muscular Dystrophy Heart Protection study |
Dr John Bourke
|
Alder Hey Children’s NHS Foundation Trust PI: Dr Stefan Spinty |
In Setup |
|
EMSC |
Validation of early morning salivary cortisol (EMSC) as a non-invasive, patient friendly, reliable, cost effective measure of adrenal reserve in children receiving inhaled corticosteroids |
Dr Jo Blair (Alder Hey Children’s NHS Foundation Trust) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Jo Blair Arrowe Park Hospital PI: Dr Atrayee Ghatak Countess of Chester Hospital PI: Dr Stephen Brearey Macclesfield Hospital PI: Dr Ang Ho Leighton Hospital PI: Dr Julie Ellison Glan Clwyd Hospital PI: Dr Peter Stutchfield Wrexham Hospital PI: Dr Yim-Yee Matthews Bangor Hospital PI: Dr Mair Parry Southport & Ormskirk Hospital PI: Dr M Zbaeda Whiston Hospital PI: Dr L Amegavie Warrington Hospital PI: Dr Nick Wild |
Closed follow up complete |
|
EPIC |
Evidence into practice: Evaluating a child-centred intervention for diabetes medicine management |
Prof Anne Williams & Prof Jane Noyes |
Wrexham Maelor Hospital PI: Dr Yim-Yee Matthews Glan Clwyd Hospital PI: Dr P Stutchfield Bangor Hospital PI: Dr Mair Parry |
Closed follow up complete |
|
EVERT |
Cryotherapy versus salicylic acid for the treatment of verrucae: A randomised controlled trial. |
Mrs E Sarah Cockayne (York University Trials Unit) |
Brownlow Hill Group Practice PI: Dr Diane Exley |
Closed follow up complete |
|
EXT BIOLOGICS |
The long-term Safety and Efficacy of Biologic Therapies in Children with Rhematic Diseases |
Dr Kimme Hyrich (University of Manchester) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Michael Beresford |
Ongoing |
|
GHT/QOL |
Implications of Growth Hormone Treatment (GHT) for Quality of life (QOL) in children |
Prof Christine Eiser & Prof Gary Butler |
No site but accrual counts |
Closed follow up complete |
|
HIVAT |
Assessing the impact and safety of home intravenous antibiotic treatment (IVAT) for children with cystic fibrosis |
Dr Claire Glasscoe (Liverpool University) |
University of Liverpool / Alder Hey Children’s NHS Foundation Trust PI: Dr Clare Glasscoe Glan Clwyd Hospital PI: Dr Lee Wisby Wrexham Hospital PI: Dr Yim-Yee Matthews Bangor Hospital PI: Dr Mair Parry Countess of Chester Hospital PI: Dr Ravi Jayaram Macclesfield Hospital PI: Dr Ang Ho Leighton Hospital PI: Dr Julie Ellison Southport & Ormskirk Hospital PI: Dr M Zbaeda Whiston Hospital PI: Dr L Amegavie Warrington Hospital PI: Dr Chris Beresford Arrowe Park Hospital PI: Dr David Lacy |
Closed follow up complete |
|
ICISS |
International Collaborative Infantile Spasms Study |
Prof John Osborne (Royal United Hospital, Bath) |
Warrington Hospital PI: Dr Nick Wild Southport & Ormskirk Hospital PI: Dr Al-Kharusi Whiston Hospital PI: Dr Azziz Leighton Hospital PI: Dr Pugh Countess of Chester Hospital PI: Dr Gibb Macclesfield Hospital PI: Dr Spillman Wrexham Maelor Hospital PI: Dr Minchom Alder Hey Children’s NHS Foundation Trust PI: Dr Rachel Kneen Arrowe Park hospital PI: Dr Adrian Hughes |
Ongoing |
|
INFORMATION MATTERS |
Health, medicines & self-care choices made by children, young people & their families: Information to support decision making. |
Prof Anne Williams & Prof Jane Noyes (Cardiff & Bangor Universities) |
Alder Hey Children’s NHS Foundation Trust PI: Dr C Bruce Whiston Hospital PI: Dr L Amegavie Southport & Ormskirk Hospital PI: Dr Susan Ohalloran |
Closed follow up complete |
|
INIS |
International Neonatal Immunotherapy Study |
Prof Peter Brocklehurst (National Perinatal Epidemiology Unit [NPEU], Oxford) |
Warrington Hospital PI: Dr Delyth Webb Countess of Chester Hospital PI: Dr Liz Newby Arrowe Park Hospital PI: Dr Oliver Rackham |
Closed follow up complete |
|
LUPUS |
UK Juvinile-onset Systemic Lupus Erythematosis cohort study and respository |
Dr Michael Beresford (Alder Hey Children’s NHS Foundation Trust) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Michael Beresford Leighton Hospital PI: Referral Site no PI |
Ongoing |
|
MAGNETIC |
MAGnesium Nebuliser Trial (MAGNETIC) – a randomised, placebo controlled study of nebulised magnesium in acute severe asthma in children. |
Dr Colin Powell (Children’s Hospital for Wales) |
Macclesfield Hospital PI: Dr Ang Ho Leighton Hospital PI: Dr Julie Ellison Southport & Ormskirk Hospital PI: Dr Matouk Zbaeda Whiston Hospital PI: Dr G Inkster Countess of Chester Hospital PI: Dr Ravi Jayaram |
Closed follow up complete |
|
MASCOT |
Management of Asthma in school age children on therapy |
Prof Warren Lenney (University Hospital of North Staffordshire NHS Trust) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Jon Couriel |
Closed follow up complete |
|
MENDS |
The use of melatonin in children with harmacogeneticsl disorders and impaired sleep: A randomised, double-blind, placebo controlled, parallel study. |
Dr Richard Appleton & Dr Paul Gringras |
Alder Hey Children’s NHS Foundation Trust PI: Dr Richard Appleton |
Closed follow up complete |
|
MYCYC |
A randomised clinical trial of mycophenolate mofetil versus cyclophosphamide for remission induction in ANCA associated vasculitis |
Dr David RW Jayne (Addenbrooke’s Hospital) |
Alder Hey Children’s NHS Foundation Trust PI: Dr E Baildam |
Closed In Follow Up |
|
NEPHROTIC SYNDROME |
Long term tapering v standard prednisolone therapy for the treatment of the initial epside of childhood nephrotic syndrome: national multicentre randomised double blind pilot study. |
Dr Richard Trompeter (Great Ormond Street Hospital for Children NHS Trust) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Caroline Jones Southport & Ormskirk Hospital PI: Dr Susan O’Halloran Warrington Hospital PI: Dr Delyth Webb Countess of Chester Hospital PI: Dr John Gibbs Arrowe Park Hospital PI: Dr Elizabeth Breen Leighton Hospital PI: Dr Julie Ellison |
Closed follow up complete |
|
P3MC |
Double-blind 3 arm parallel group randomised placebo controlled trial of Propranolol & Pizotifen in preventing migraine in children |
Dr William Whitehouse (University of Nottingham) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Andrew Curran Arrowe Park Hospital PI: Dr Adrian Hughes |
Closed follow up complete |
|
PASS |
Pharmacogenetics of Adrenal Suppression with inhaled steroids |
Prof Munir Pirmohamed & Prof Rosalind Smyth |
Alder Hey Children’s NHS Foundation Trust PI: Dr Daniel Hawcutt Countess of Chester Hospital PI: Dr Stephen Brearey Macclesfield Hospital PI: Dr Ang Ho Leighton Hospital PI: Dr Julie Ellison Glan Clwyd Hospital PI: Dr Peter Stutchfield Wrexham Hospital PI: Dr Yim-Yee Matthews Bangor Hospital PI: Dr Mair Parry Southport & Ormskirk Hospital PI: Dr M Zbaeda Whiston Hospital PI: Dr L Amegavie Warrington Hospital PI: Dr Nick Wild Arrowe Park Hospital PI: Dr David Lacy |
Ongoing |
|
POPs |
Prevention & treatment of steroid induced osteopaenia in children and adolescents with Rheumatic disease |
Dr Madeline Rooney (MERU QUB Musgrave Park Hospital, Belfast) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Michael Beresford |
Ongoing |
|
RECRUIT |
Processes in recruitment to randomised controlled trials of medicine (RCT) of medicines for children |
Dr Bridget Young (University of Liverpool) |
Alder Hey Children’s NHS Foundation Trust Liverpool Women’s Hospital PI’s not required |
Closed follow up complete |
|
SLEEPS |
Safety profile, efficacy and equivalence in paediatric ntensive care sedation. |
Prof Andy Wolf (Bristol Royal Children’s) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Kate Parkins |
Ongoing |
|
TIPIT |
Thyroxine in Pre term infants |
Prof Weindling (University of Liverpool, Liverpool Women’s Hospital) |
Liverpool Women’s Hospital PI: Dr Sze May NG Arrowe Park Hospital PI: Dr Donal Manning |
Closed follow up complete |
|
SCAMP |
Macronutrient intake, growth and other aspects of neonatal care |
Dr Colin Morgan |
Alder Hey Children’s NHS Foundation Trust PI: Dr Mark Turner Liverpool Women’s Hospital PI: Dr Mark Turner Macclesfield Hospital PI: TBC |
Ongoing |
|
ADNAT |
Development of an adolescent Diabetes Needs Assessment Tool |
Prof Helen Cooper |
Alder Hey Children’s NHS Foundation Trust PI: Dr Mohammed Didi Warrington Hospital PI: Dr Nick Wild Countess of Chester Hospital PI: Paul Langridge Arrowe Park Hospital PI: Dr peter Todd Leighton Hospital PI: Dr Harold Sackey Whiston Hospital PI: J Mimnagh (DSN) |
Closed follow up complete |
|
MODRIC |
Formulations |
Prof Tony Nunn |
Alder Hey Children’s NHS Foundation Trust PI: Prof A Nunn |
Closed follow up complete |
|
MTX BLOOD SPOTS |
Use of dried blood spots to measure methotrexate levels |
Prof J McElnay |
Alder Hey Children’s NHS Foundation Trust PI: Dr Michael Beresford |
Ongoing |
|
GAS |
Comparing regional and general anaesthesia for effects on neurodevelopmental outcome and apnoea in infants |
Dr Neil S Morton |
Alder Hey Children’s NHS Foundation Trust PI: Dr Annette Davis Liverpool Womens Hospital PI: TBC Warrington Hospital PI: TBC |
Closed follow up complete |
|
WINRP |
Study of Warfarin dosing, INR and harmacogenetics in paediatric patients. A retrospective cohort study of children and young people taking Warfarin. |
Prof Munir Pirmohamed |
Alder Hey Children’s NHS Foundation Trust PI: Dr Dan Hawcutt |
Ongoing |
|
SRNS (RaDaR) |
National Studies of Kidney Disease in Childhood and Adolescence |
Prof Moin Saleem |
Alder Hey Children’s NHS Foundation Trust PI: Dr David Ansell |
Ongoing |
|
PUDDLS |
A prospective UK study of the clinical features and outcome of children with CNS demyelinating disease |
Dr Evangeline Wassmer |
Alder Hey Children’s NHS Foundation Trust PI: Dr Rachel Kneen |
Ongoing |
|
JDCBS |
Juvenile Dermatomyositis cohort Biomarker Study and Repository (UK & Ireland) |
Dr Lucy Wedderburn |
Alder Hey Children’s NHS Foundation Trust PI: Dr Liza McCann |
Ongoing |
|
TORPEDO-CF |
Trial of Optimal Therapy for Pseudomonas Eradication in Cystic Fibrosis |
Dr Simon Langton Hewer |
Alder Hey Children’s NHS Foundation Trust PI: Dr Kevin Southern |
Ongoing |
|
KKR |
Teaching parents to become home-based car-givers of children’s long term kidney conditions: a mixed methods study in all UK Children’s Kideney Units. |
Dr Veronica Swallow |
Alder Hey Children’s NHS Foundation Trust PI: Alison Birch |
Closed follow up complete |
|
JUMP |
Type 2 Diabetes in Childhood: Building a platform for interventions to prvent the progression to cardiovascular disease. |
Prof Tim Barrett |
Alder Hey Children’s NHS Foundation Trust PI: Dr Jo Blair Countess of Chester hospital PI: TBC |
Ongoing |
|
CATCH |
A randomised controlled trial comparing the effectiveness of heparin bonded or antibiotic impregnated central venous catheters with standard conetral venous catheters for the prevention of hospital acquired blood stream infection in children |
Prof Ruth Gilbert |
Alder Hey Children’s NHS Foundation Trust PI: Dr S Kerr |
Ongoing |
|
KONCERT |
A study of the pharmacokinetics, safety and efficacy of twice-daily versus once-daily lopinavir/ritonavir tablets dosed by weight as part of combination antiretroviral therapy in HIV-1 infected children. |
Dr Herminone Lyall |
Alder Hey Children’s NHS Foundation Trust PI: Dr Andrew Riordan |
Ongoing |
|
I2S2 |
A randomised control trial of iodine supplementation in preterm infants. |
Prof Peter Brocklehurst |
Step Down Sites only |
Ongoing |
|
MAGIC |
(Molecular genetics of Adverse Drug Reaction in Children) |
Prof Munir Pirmohamed |
Alder Hey Children’s NHS Foundation Trust PI: Dr Dan Hawcutt |
Ongoing |
|
SCIPI |
SubCutaneous Insulin: Pumps or Injections |
Dr Joanne Blair |
Alder Hey Children’s NHS Foundation Trust PI: Dr Mohammed Didi |
Ongoing |
|
MPGN (RaDaR) |
National Study of membranoproliferative glomerulonephritis |
Dr C Mark Taylor |
Alder Hey Children’s NHS Foundation Trust PI: Dr Caroline Jones |
Ongoing |
|
EUROPAC 2 |
Antioxidants and Magnesium in chronic pancreatitis |
Mr M Raraty |
Alder Hey Children’s NHS Foundation Trust PI: Dr Mark Dalzell |
Ongoing |
|
PREDNOS |
PREDnisolone in NephrOtic Syndrome: The PREDNOS study |
Dr Nick Webb |
Alder Hey Children’s NHS Foundation Trust PI: Dr Caroline Jones Countess of Chester Hospital PI: Dr John Gibbs Macclesfield Hospital PI: Dr Ang Ho Arrowe Park Hospital PI: TBC |
Ongoing |
|
CACE |
Comparing Adults’ and Children’s Experiences of Recruitment to a Clinical Trial |
Dr Bridget Young |
Alder Hey Children’s NHS Foundation Trust PI: Dr Kevin Southern |
Ongoing |
|
REJUMEC |
Refractory Juvenile Myoclonic Epilepsy Cohort |
Prof A Marson |
Alder Hey Children’s NHS Foundation Trust PI: Dr Kevin Southern Ormskirk District General Hospital PI: TBC |
Suspended |
|
TINN-PK |
Evaluate the pharmacokinetics and tolerability of ciprofloxacin in neonates with suspected or proven Gram Negative infection |
Dr M Turner |
Alder Hey Children’s NHS Foundation Trust PI: Dr S Mahoney Liverpool Women’s Hospital PI: Dr M Turner
|
Ongoing |
|
SABRE |
Hypertonic Saline in Acute Bronchiolitis: Randomised Controlled Trial and Economic Evaluation |
Prof Mark Lloyd Everard |
Alder Hey Children’s NHS Foundation Trust PI: Dr Paul McNamara |
Ongoing |
|
SAGhE |
Safety and Appropriateness of Growth Hormone treatments in Europe |
Prof Gary Butler |
Alder Hey Children’s NHS Foundation Trust PI: Dr Jo Blair |
Ongoing |
|
SYCAMORE |
Adalimumab in Combination with Methotrexate for the Treatment of Juvenile Idiopathic Arthritis Associated Uveitis |
A V Ramanan |
Alder Hey Children’s NHS Foundation Trust PI: Dr Gavin Cleary |
Ongoing |
|
WAIT |
Wheeze and Intermittent Treatment |
Prof Jonathan Grigg (St Bartholomews Hospital) |
Alder Hey Children’s NHS Foundation Trust PI: Dr Paul McNamara Arrowe Park Hospital PI: Dr David Lacy Countess of Chester Hospital PI: Dr John Gibbs Whiston Hospital PI: TBC Southport & Ormskirk Hospital PI: Dr Sharryn Gardner Macclesfield Hospital PI: Dr Sheng-Ang Ho |
Ongoing |
|
TRIALNET NATURAL HISTORY |
Natural History study of the Development of Type 1 Diabetes |
Prof Polly Bingley |
Alder Hey Children’s NHS Foundation Trust PI: Dr Princy Paul Countess of Chester Hospital PI: TBC
|
In Setup |
|
ESNEE |
European Study of Neonatal Excipient Exposure (ESNEE): An observational study of excipient kinetics in neonates |
Dr Mark Turner |
Alder Hey Children’s NHS Foundation Trust PI: TBC Liverpool Women’s Hospital PI: Dr M Turner |
In Setup |
|
PIPS |
Early administration to preterm infants of the probiotic Bifidobacterium breve BBG to prevent sepsis and Necrotising Enterocolitis |
Prof Kate Costeloe |
Leighton Hospital PI: Dr A Thirumirugan
|
In Setup |
Industry Sponsored Studies
|
MCRN008 |
Endocrinology |
Closed follow up complete |
|
MCRN020 |
Respiratory |
Closed follow up complete |
|
MCRN000 |
Endocrinology |
Closed follow up complete |
|
MCRN001 |
Cystic Fibrosis |
Closed follow up complete |
|
MCRN007 |
Endocrinology |
Closed In Follow Up |
|
MCRN037 |
Respiratory |
Closed follow up complete |
|
MCRN011 |
Rheumatology |
Closed In Follow Up |
|
MCRN016 |
Respiratory |
Closed follow up complete |
|
MCRN036 |
Respiratory |
Closed follow up complete |
|
MCRN049 |
Rheumatology |
Closed In Follow Up |
|
MCRN053 |
Neonatal – PK |
Closed In Follow Up |
|
MCRN021 |
Neurosciences |
Closed In Follow Up |
|
MCRN022 |
Neurosciences |
Closed In Follow Up |
|
MCRN035 |
Pharmacokinetic |
Ongoing |
|
MCRN065 |
Respiratory |
Suspended |
|
MCRN067 |
Rheumatology |
Closed follow up complete |
|
MCRN068 |
Rheumatology |
Closed In Follow Up |
|
MCRN069 |
Rheumatology |
Ongoing |
|
MCRN071 |
Neurosciences |
Closed In Follow Up |
|
MCRN095 |
Diabetes |
Ongoing |
|
MCRN080 |
Gastroenterology |
Ongoing |
|
MCRN112 (ADHD) |
Neurology |
Ongoing |
|
MCRN109 (AMAG) |
Nephrology |
In Setup |
|
MCRN110 (AMAG) |
Nephrology |
In Setup |
|
MCRN114 (Diabetes) |
Diabetes |
Closed follow up complete |
|
MCRN129 |
Gastroenterology |
Ongoing |
|
MCRN148 |
Neurosciences |
Ongoing |
